Echocardiographic assessment of pulmonary artery systolic pressure following treadmill stress testing

Khan, Arshad A.; Al-Omary, Mohammad; Renner, Ian; Haque, Ehtesham Ul; Ekmejian, Avedis; Hussain, Mumtaz; Quiqueree, Laurent; Collins, Nicholas J.; Turner, Stuart

Title: Echocardiographic assessment of pulmonary artery systolic pressure following treadmill stress testing
Creator: Khan, Arshad A.; Al-Omary, Mohammad; Renner, Ian; Haque, Ehtesham Ul; Ekmejian, Avedis; Hussain, Mumtaz; Quiqueree, Laurent; Collins, Nicholas J.; Turner, Stuart
Relation: European Heart Journal - Cardiovascular Imaging Vol. 18, Issue 11, p. 1278-1282
Publisher Link: http://dx.doi.org/10.1093/ehjci/jew308
Publisher: Oxford University Press
Resource Type: journal article
Date: 2017
Description: Aims: The use of treadmill stress echocardiography (SE) for the diagnosis of nascent pulmonary hypertension (PH) has been hampered by a lack of well-defined, post-exercise pulmonary artery systolic pressure (PASP) values across representative age groups in a normal cohort. Methods and results: Five hundred and eleven subjects (mean age: 53 ±14, 68% female) with normal resting PASP were included in the study. All participants performed treadmill exercise using the Bruce protocol to a high level of perceived exertion. PASP was calculated before and immediately after exercise using Doppler assessment of tricuspid regurgitation. For the cohort, post-exercise PASP was 39 ± 7 mmHg (range: 23–64 mmHg) representing an increase of 11 ± 6 mmHg (44%) from resting values (P < 0.001). The 95th centile values for post-exercise PASP were calculated for the following age cohorts: <30 years; 46 mmHg, 31–50 years; 50 mmHg, 51–70 years; 52 mmHg, >70 years; 53 mmHg. There was a modest independent correlation between post-exercise PASP and (i) increasing age and (ii) resting PASP (r² = 0.35 and 0.49, respectively, P = 0.01). Conclusion: An increase of post-exercise PASP was seen in all patients undergoing SE in this study. Age was directly correlated with post-exercise PASP. Using normative data from healthy controls, treadmill SE-derived post-exercise PASP may be a useful adjunct in the diagnosis of PH.
Subject: pulmonary artery systolic pressure; stress echocardiography; pulmonary hypertension
Identifier: http://hdl.handle.net/1959.13/1354387
Identifier: uon:31260
Identifier: ISSN:2047-2404
Language: eng
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